Tonight we had a power down of the servers. We are still recovering from it as one disk seems to be not functional.

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As many of you have already noticed, we are experiencing some issues with our work unit generators. We are working on a fix right now and will hopefully be back up to speed soon. Thanks for your patience.

A batch of 500 WUs *_TRYP_* have been sent and will take TWICE as much to compute than normal.We are talking of 10 nanoseconds of simulation per WU! (for what most people still use big fat supercomputers). We need them for a very interesting publication we are preparing related to this experiment. Many thanks for the effort!

English: The downtime went well and we are now running again as before. However due to the server being down, we got a lot of workunits back at once and the server is playing catchup again right now. The shortage will hopefully be over soon. Deutsch: Waehrend der Downtime lief alles gut - die neuen Serverdienste laufen fehlerfrei. Allerdings bekamen wir aufgrund der Downtime eine Menge Workunits zur gleichen Zeit zurueck, weswegen der Server nun mit einsortieren ausgelastet ist. Sobald er mit Einsortieren fertig ist, werden wieder ausreichend Workunits zur Verfuegung stehen.

Thanks to all volunteers for their contribution in the run of all *JAN* tasks which finally lead to this scientific publication:
J. Selent, F. Sanz, M. Pastor and G. De Fabritiis, Induced Effects of Sodium Ions on Dopaminergic G-Protein Coupled Receptors, PLOS computational biology, 6, e1000884 (2010).

Download it here: http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000884

In this work we show how sodium ion can modulate the activity of an important protein receptor (dopamine D2 GPCR) a drug target for the treatment of diverse central nervous system disorders (e.g. schizophrenia, Parkinson’s disease).

English: On Monday the 23rd we will have a longer downtime period starting from 9:00 am CEST. During this period we will install the new server daemons needed for our next generation POEM++. The website should only be down for a couple of minutes if everything goes alright. The BOINC infrastructure underneath and also the mysql server will be down a bit longer. Thanks for your help and sorry for the inconvenience. Deutsch: Von nun an gibts die News auch in Deutsch: Am Montag den 23. wird es eine längere Downtime geben. Waehrend dieser Downtime installieren wir hier die serverseitigen Daemons fuers neue POEM++. Die Webseite sollte nur ein paar Minuten down sein, wenn alles gut geht (und ist auch schon wieder da). Die BOINC Infrastruktur und der MySQL Server werden etwas laenger down sein. Danke fuer eure enorme Hilfe und bitte entschuldigt den kurzen Ausfall.

The project has been updated, the server is now working

The project will be available ony intermittently on Wed Aug 11 from 11.00am CET due to system maintenance.

Rosetta@home related advances have been featured in the national media twice in the last month. The first advance was the design of a protein catalyst that joins two molecules in a way not found in Nature; this was reported in Science magazine in July. The second advance is the finding that FoldIt players can solve hard structure prediction problems; this was reported in Nature magazine this week. These advances were covered in the New York Times, the LA times, and likely in your local newspaper. Thanks to all of you for your contributions to Rosetta@home!

Finally the CASP protein structure assessment is over. Thanks to you we could process all HUMAN/SERVER targets in this year of CASP. Currently not all experimental structures are available for comparison with our prediction; we will keep you posted once they are. A big thanks again for making this huge effort and our participation possible!

There was serious problem during the server upgrade yesterday, and we finally managed to recover the server. We apologize for the inconvenience.